Organ on chip integration and applications of the same

US10119622B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• Frank E. Block, III · Nashville, US
• Philip C. Samson · Nashville, US
• Erik Morgan Werner · Irvine, US
• Dmitry A. Markov · Nashville, US
• Ronald S. Reiserer · Nashville, US
• Jennifer Robin McKenzie · Nashville, US
• David E. Cliffel · Nashville, US
• William J. Matloff · Paradise Valley, US
• Frank E. Block, Jr. · Nashville, US
• Joseph R. Scherrer · Nashville, US
• W. Hunter Tidwell · Nashville, US
• John P. Wikswo · Brentwood, US

Key dates

• Filing date: Nov 29, 2017
• Grant date: Nov 6, 2018
• Expiry date: Nov 29, 2037

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2400/0655
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A rotary planar peristaltic micropump (RPPM) includes an actuator having a shaft engaged with a motor such that activation of the motor causes the shaft to rotate, and a bearing assembly engaged with the shaft. The bearing assembly has a bearing cage defining a plurality of spaced-apart openings thereon, and a plurality of rolling-members accommodated in the plurality of spaced-apart openings of the bearing cage, such that when the shaft rotates, the plurality of rolling-members of the bearing assembly rolls along a circular path. The RPPM also includes a fluidic path in fluidic communication with first and second ports. The fluidic path is positioned under the actuator and coincident with the circular path, such that when the shaft of the actuator rotates, the plurality of rolling-members of the bearing assembly rolls along the fluidic path to cause a fluid to transfer between the first and second ports.