Method of assaying an individual for immune impairment

US10119959B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Shai S. SHEN-ORR · Menlo Park, US
• Atul J. Butte · Menlo Park, US
• Mark M. Davis · Mountain View, US
• David Furman · Kinnelon, US
• Brian A. Kidd · Palo Alto, US

Key dates

• Filing date: Jun 25, 2011
• Grant date: Nov 6, 2018
• Expiry date: Jan 10, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/60
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers obtained from various analyzes, primarily from blood, testing immune function including the analysis of immune cell subset frequencies, gene expression, cytokine and chemokine levels, and signaling responses to stimulation with cytokines (‘cytokine response’). Particular combinations of markers can predict with high accuracy whether an individual will respond to active vaccination and become protected against recurring diseases.