Tissue thickness compensator comprising controlled release and expansion

US10123798B2 · kind B2 · utility

Assignee

• Ethicon, Inc. · US

Inventors

• Chester O. Baxter, III · Loveland, US
• Frederick E. Shelton, IV · Hillsboro, US
• Charles J. Scheib · Loveland, US
• Christopher W. Widenhouse · Clarksville, US
• William B. Weisenburgh, II · Maineville, US
• John L. Stammen · Cincinnati, US
• Mark H. Ransick · Sharonville, US
• Stephanie A. Mutchler · Loveland, US
• Gary W. Knight · Sharonville, US
• Michael S. Cropper · Edgewood, US
• Sean P. Conlon · Loveland, US
• Jeffrey S. Swayze · Hamilton, US

Key dates

• Filing date: Mar 28, 2012
• Grant date: Nov 13, 2018
• Expiry date: Aug 27, 2034

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F04C2270/0421
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A tissue thickness compensator may generally comprise a first layer comprising a first biocompatible material sealingly enclosed in a water impermeable material and a second layer comprising a second biocompatible material comprising at least one encapsulation, wherein the first biocompatible material expands when contacted with a fluid. The tissue thickness compensator may comprise a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a medicament, and/or pharmaceutically active agent. The encapsulation may comprise a biodegradable material to degrade in vivo and/or in situ. The tissue thickness compensator may comprise a hydrogel. The reaction product may comprise a fluid-swellable composition. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.