Cyclic ureas as inhibitors of rock

US10123993B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Peter W. Glunz · Wilmington, US
• Doree F. Sitkoff · Dresher, US
• Navnath Dnyanoba Yadav · Bengaluru, IN
• Mandar Shrikrishna Bodas · Bengaluru, IN
• Rajeev S. Bhide · Princeton Junction, US
• Sharanabasappa Patil · Raichur, IN
• Kumaresan Chinnakotti · Sankarankovil, IN
• Prasanna Savanor Maddu Rao · Sagara, IN
• Jeevan Prakash Shetty · Bengaluru, IN

Key dates

• Filing date: Jan 8, 2016
• Grant date: Nov 13, 2018
• Expiry date: Jan 8, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.