Oncolytic adenovirus encoding a B7 protein or active fragment
US10124028B2 · kind B2 · utility
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2References
18Claims
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Key dates
| Filing date | Aug 8, 2016 |
| Grant date | Nov 13, 2018 |
| Priority date | — |
| Expiry date | Oct 24, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/10371
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides a replication competent oncolytic adenovirus with selectivity for cancer cells, wherein the adenovirus comprises a transgene under the control of a promoter endogenous to the virus, wherein the transgene comprises a DNA sequence encoding a B7 protein or an active fragment thereof, compositions comprising same, methods of generating the viruses, and use of the viruses and compositions in treatment, particularly in the treatment of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.