Mutant OPAA enzymes with increased catalytic efficiency on organophosphorus compound EA1356
US10124043B1 · kind B1 · utility
2Cited by
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21Claims
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Key dates
| Filing date | Feb 14, 2018 |
| Grant date | Nov 13, 2018 |
| Priority date | — |
| Expiry date | Feb 14, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/08002
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention comprises isolated, mutant, non-wild-type organophosphorus acid anhydrolase (OPAA) enzymes having three site mutations, methods of production, and methods of use to effectively degrade organophosphorus compound EA1356 (2-methylcyclohexyl methylphosphonofluoridate) with greater catalytic efficiency than the wild-type OPAA enzyme.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.