Lipids and lipid compositions for the delivery of active agents

US10124065B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Jeremy Lee Baryza · Mountain View, US
• Rohan Eric John Beckwith · Cambridge, US
• Keith Bowman · Harleysville, US
• Crystal Byers · Brookline, US
• Tanzina Fazal · Cambridge, US
• Gabriel Grant Gamber · Cambridge, US
• Cameron Chuck-munn Lee · Cambridge, US
• Ritesh Bhanudasji Tichkule · Cambridge, US
• Chandra Vargeese · Schwenksville, US
• Shuangxi Wang · El Monte, US
• Laura West · Weymouth, US
• Thomas Zabawa · Boston, US
• Junping Zhao · Arlington, US

Key dates

• Filing date: Mar 6, 2014
• Grant date: Nov 13, 2018
• Expiry date: Mar 6, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.