Bionanofluid for use as a contrast, imaging, disinfecting and/or therapeutic agent

US10124075B2 · kind B2 · utility

Assignee

• The Royal Institution for the Advancement of Learning/McGill University · CA

Inventors

• Mark Trifiro · Montréal, CA
• Miltiadis Paliouras · Laval, CA
• Philip ROCHE · Mount Royal, CA
• Idit Dotan · Toronto, CA
• Lenore Beitel · Montréal, CA
• Carlos Alvarado · Houston, US
• Matthew Carnevale · Medford, US
• Elliot Jonathan Mitmaker · Thurso, CA

Key dates

• Filing date: Nov 14, 2014
• Grant date: Nov 13, 2018
• Expiry date: Nov 14, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2389/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A bionanofluid includes a carbon-based nanomaterial substantially mono-dispersed in a fluid. The carbon-based nanomaterial is surface modified with a polar group when the fluid is polar or with a non-polar group when the fluid is non-polar, and functionalized with a biological targeting moiety to allow specific association of the carbon-based nanomaterial to a targeted entity. A hybrid bionanofluid includes the bionanofluid, with the carbon-based nanomaterial further modified with a hybrid nanoparticle which includes an alloy, transition metal, semi-conductor, semi-metal or polymer based nanoparticle with biological targeting moiety. A hydrogel, foam, cream, spray or dried product includes the bionanofluid or hybrid bionanofluid. The bionanofluid or hybrid bionanofluid are useful in multimodal imaging (photo-luminescence, luminescence, photo-acoustic, MRI, ultrasound) and/or cellular targeting.