Lipids and lipid compositions for the delivery of active agents

US10125092B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Rohan Eric John Beckwith · Cambridge, US
• Luis Brito · Cambridge, US
• Brian Addison DECHRISTOPHER · Mountain View, US
• Gabriel Grant Gamber · Cambridge, US
• Andrew Geall · Littleton, US
• Thomas Zabawa · Boston, US

Key dates

• Filing date: Sep 4, 2015
• Grant date: Nov 13, 2018
• Expiry date: Sep 4, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/15
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides for a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein RA, RB, R2 and R4 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.