Kinase inhibitors
US10125100B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 24, 2017 |
| Grant date | Nov 13, 2018 |
| Priority date | — |
| Expiry date | May 24, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/048
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are provided compounds of formulas III and VIIa: or a salt or protected derivative thereof, wherein Z2 represents a structural fragment of formula V, wherein R1A to R1E, R2 to R4, R5a, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity, for example through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.