Formation of macromolecules using iterative growth and related compounds

US10125124B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Jeremiah A. Johnson · Boston, US
• Jonathan C. Barnes · Waltham, US
• Deborah June Choi Ehrlich · Cambridge, US
• Yivan Jiang · Revere, US
• Angela Xiaodi Gao · Cambridge, US

Key dates

• Filing date: Mar 18, 2016
• Grant date: Nov 13, 2018
• Expiry date: Mar 18, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G65/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In some embodiments, macromolecules and related methods are provided. In some embodiments, an iterative growth process may be used to form a macromolecule comprising one or more repeat units comprising a functionalizable pendant group, with precise control over mass, length, backbone sequence, pendant group sequence, and/or stereochemistry, amongst other features. Macromolecules (e.g., non-natural macromolecules) form from the iterative growth process, described herein, may be used for a wide variety of applications, including the delivery of active agents.