Process for preparing D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide

US10125164B2 · kind B2 · utility

Assignee

• FLAMMA SPA · IT

Inventors

• Xinjun Zhao · Dalian, CN
• Minyu Zheng · Dalian, CN
• Xiaozhong Yu · Shenyang, CN
• Hanrong Gao · Ames, US
• Fabrice Cornille · Les Ulis, FR

Key dates

• Filing date: Jun 24, 2015
• Grant date: Nov 13, 2018
• Expiry date: Jul 25, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/0812
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.