Method and thermal conductivity detector
US10126277B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 2016 |
| Grant date | Nov 13, 2018 |
| Priority date | — |
| Expiry date | Jan 26, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/625
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A thermal conductivity detector includes a heatable resistive detector configured to be physically arranged in an analytes flow eluting from a chromatography column and electrically arranged with resistors in separate arms of a measuring bridge, an amplifier which detects differential voltage between two opposite nodes of the bridge and applies an output voltage to other opposite nodes of the measuring bridge to maintain the detector at a constant operating temperature, and an additional resistor with a controllable switch in parallel connected in series with the detector or resistor arranged in one arm of the bridge, where the switch is periodically turned on and off at a predetermined duty cycle and/or controlled by information on characteristic times-of-arrival of analytes at the detector to compensate for operating temperature uncertainties due to manufacturing variations of the resistors and/or to allow for processing small and large peaks of a chromatogram with highest available resolution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.