Method of producing oligomer affinity pairs
US10127349B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Jul 18, 2011 |
| Grant date | Nov 13, 2018 |
| Priority date | — |
| Expiry date | Dec 14, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B25/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The invention provides methods to identify pRNA- and pDNA oligomer affinity pairs. Affinity pairs comprised of nucleic acid oligomers which demonstrate no cross-reactivity (“orthogonal”) are designed using software and empirically verified by thermodynamic study and lateral flow testing. The design software uses a semi-random algorithm to build such sequences of nucleic acid oligomers based on user-input parameters for affinity strength and orthogonal stringency. These pairs can be applied for use in multi-analyte solid support and lateral flow diagnostic tests.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.