Topical delivery of skin compositions having low pH

US10130578B2 · kind B2 · utility

Assignee

• Johnson & Johnson Consumer Inc. · US

Inventors

• Anne-Sophie Brillouet · Los Angeles, US
• Marisa DeVita Dufort · Fryeburg, US
• Ali Fassih · Flemington, US
• Devin Garcia · Middlesex, US
• Ya-Ping Hu · Somerville, US
• Wen-Hwa Ting Li · Cranbury, US
• Ramine Parsa · Lawrenceville, US
• Jyotsna Paturi · Skillman, US
• Dianne Rossetti · Readington, US
• Ying Sun · Waltham, US
• Janet Wangari-Talbot · Fryeburg, US
• Robert Wayne Yates · Warminster, US

Key dates

• Filing date: Jul 23, 2015
• Grant date: Nov 20, 2018
• Expiry date: Jul 23, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2800/592
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Low pH compositions for topical administration to skin are provided. They comprise a buffering agent having a pKa of about 2.8 to about 4.2 and a cosmetically acceptable active ingredient having a pKa within about 1 unit of the pKa of the buffering agent. The composition has a pH of about 3.3 to 4 and a buffer capacity of at least about 0.15. A method of increasing the topical delivery of a cosmetically acceptable active ingredient having a pKa of about 2.8 to about 4 is also provided.