Taste-masked pharmaceutical compositions
US10130580B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 20, 2018 |
| Grant date | Nov 20, 2018 |
| Priority date | — |
| Expiry date | Apr 20, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2077
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is provided a method for preparing an orally disintegrating tablet (ODT) composition comprising microparticles of one or more taste-masked active pharmaceutical ingredient(s), rapidly-dispersing microgranules, and other optional, pharmaceutically acceptable excipients wherein the ODT disintegrates on contact with saliva in the buccal cavity in about 60 seconds forming a smooth, easy-to-swallow suspension. Furthermore, the microparticles (crystals, granules, beads or pellets containing the active) applied with a taste-masking membrane comprising a combination of water-insoluble and gastrosoluble polymers release not less than about 60% of the dose is in the stomach in about 30 minutes, thus maximizing the probability of achieving bioequivalence to the reference IR product having rapid onset of action (short Tmax). A process for preparing such compositions for oral administration using conventional fluid-bed equipment and rotary tablet press is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.