Treatment of joint pain

US10130628B2 · kind B2 · utility

Assignees

• Unity Biotechnology, Inc. · US
• BUCK INSTITUTE FOR RESEARCH ON AGING · US
• THE JOHNS HOPKINS UNIVERSITY · US
• Mayo Foundation for Medical Education and Research · US

Inventors

• Nathaniel David · Brisbane, US
• Albert Davalos · San Rafael, US
• Remi-Martin Laberge · San Francisco, US
• Judith Campisi · Berkeley, US
• Marco Demaria · Groningen, NL
• Alain P. Vasserot · South San Francisco, US
• Chaekyu Kim · Pikesville, US
• Okhee Jeon · Baltimore, US
• Jennifer H. Elisseeff · Baltimore, US
• James L. Kirkland · Rochester, US
• Tamar Tchkonia · Rochester, US
• Yi Zhu · Chengdu, CN

Key dates

• Filing date: Apr 6, 2017
• Grant date: Nov 20, 2018
• Expiry date: Apr 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/485
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides a technology for managing the sensation of pain in a subject in need thereof. Treatment methods according to this invention include administering to the subject a formulation that contains an effective amount of (4-[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone).