Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists

US10131655B2 · kind B2 · utility

Assignee

• DR. REDDY'S LABORATORIES LIMITED · IN

Inventors

• Pradip Kumar Sasmal · Hyderabad, IN
• Chintakunta Vamseekrishna · Hyderabad, IN
• Vijay Potluri · Hyderabad, IN
• Ashok Tehim · Ridgewood, US
• Yonghua Gai · North Grafton, US
• Hang Zhang · Ottawa, CA

Key dates

• Filing date: Sep 19, 2016
• Grant date: Nov 20, 2018
• Expiry date: Sep 19, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. wherein R1, R2, R3, R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.