Patent · US Active

Di- and triphosphate prodrugs

US10131685B2 · kind B2 · utility

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13Claims

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Assignee

Universitaet Hamburg · DE

Inventors

Chris Meier · Jork, DE
Tristan Gollnest · Ahrensburg, DE
Tobias Nack · Hamburg, DE
Lina Weinschenk · Hamburg, DE

Key dates

Filing date	Aug 17, 2015
Grant date	Nov 20, 2018
Priority date	—
Expiry date	Aug 17, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F9/65586
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds which can be used as prodrugs, in particular nucleoside diphosphate and triphosphate prodrugs, and a method for producing these compounds. The aim is to provide improved di- and/or triphosphate prodrugs, in particular nucleotide or nucleotide analog prodrugs. This is achieved in one aspect by providing bioreversibly and asymmetrically masked di- and triphosphate compounds, in particular nucleoside diphosphate and nucleoside triphosphate compounds or the analogs thereof. The masking only occurs at the terminal phosphate, i.e. at the β- or γ-phosphate, whereas the masking of the internal phosphate is omitted.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.