Compositions and methods for specific regulation of pyruvate dehydrogenase kinase

US10131691B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Daria Mochly-Rosen · Menlo Park, US
• Nir Qvit · Menlo Park, US
• Marie-Helene Disatnik Dziesietnik · Palo Alto, US

Key dates

• Filing date: Nov 17, 2015
• Grant date: Nov 20, 2018
• Expiry date: Dec 25, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A peptide composition is provided which specifically inhibits the ability of δ-protein kinase C (δPKC) to phosphorylate pyruvate dehydrogenase kinase (PDK) under ischemic conditions. The peptide composition is useful for treating or reducing tissue damage resulting from ischemia and/or reperfusion.