Methods for epicardial differentiation of human pluripotent stem cells
US10131878B2 · kind B2 · utility
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Key dates
| Filing date | Apr 5, 2016 |
| Grant date | Nov 20, 2018 |
| Priority date | — |
| Expiry date | Jul 30, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/54
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for generating high-yield, high-purity epicardial cells are described. Wnt/β-catenin signaling is first activated in human cardiac progenitor cells, by, for example, inhibiting Gsk-3 to induce differentiation into epicardial cells. Methods for long-term in vitro maintenance of human cardiac progenitor cell-derived epicardial cells and method comprising chemically defined, xeno-free, and albumin-free culture conditions are also provided.
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