Profiling peptides and methods for sensitivity profiling

US10132797B2 · kind B2 · utility

Assignee

• TOLERO PHARMACEUTICALS, INC. · US

Inventors

• David J. Bearss · Alpine, US
• Adam Siddiqui-Jain · South Jordan, US
• Clifford J. Whatcott · Lehi, US
• Peter W. Peterson · Salt Lake City, US
• Steven L. Warner · Sandy, US
• Lars Mouritsen · Lehi, US

Key dates

• Filing date: Dec 19, 2017
• Grant date: Nov 20, 2018
• Expiry date: Dec 19, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure is generally directed to profiling peptides, compositions, and kits, as well as methods of use thereof. The profiling peptides comprise an Mcl-1 binding domain, and optionally a cellular uptake moiety. The methods of using such profiling peptides include predicting sensitivity of a cancer, selecting a treatment, treating a cancer, producing a sensitivity profile, and the like.