Integrated sample processing for electrospray ionization devices

US10134576B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• John Scott Mellors · Carrboro, US
• John Michael Ramsey · Chapel Hill, US
• Nicholas George Batz · Carrboro, US

Key dates

• Filing date: Nov 13, 2017
• Grant date: Nov 20, 2018
• Expiry date: Nov 13, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N30/7266
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer.