Methods and compositions for expanding long-term hematopoietic stem cell populations
US10137154B2 · kind B2 · utility
0Cited by
0References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 14, 2014 |
| Grant date | Nov 27, 2018 |
| Priority date | — |
| Expiry date | Sep 17, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2502/1157
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.