Self-regulating device for modulating inflammation

US10137236B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Yoram Vodovotz · Dorpsstraat, US
• Alexey Solovyev · Pittsburgh, US
• David O. Okonkwo · Pittsburgh, US
• Maxim Mikheev · Jefferson Hills, US
• Qi Mi · Pittsburgh, US
• Jorg Gerlach · Berlin, DE
• Gregory M. Constantine · Baden, US

Key dates

• Filing date: Jun 11, 2014
• Grant date: Nov 27, 2018
• Expiry date: Dec 25, 2035

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01D63/026
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.