Methods and compounds for restoring mutant p53 function
US10138219B2 · kind B2 · utility
5Cited by
5References
46Claims
0Family size
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Key dates
| Filing date | Feb 17, 2017 |
| Grant date | Nov 27, 2018 |
| Priority date | — |
| Expiry date | Feb 17, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/107
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.