Substituted benzamides as RIPK2 inhibitors

US10138222B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Jianwen CUI · Ridgefield, US
• Donghong Amy Gao · Hopewell Junction, US
• Pingrong Liu · Southbury, US
• Bryan McKibben · White Plains, US
• Craig Andrew Miller · Penfield, US
• Hossein Razavi · Danbury, US
• Elizabeth Spencer · Southbury, US
• Sabine K. Ruppel · New Milford, US
• Anil Kumar Padyana · Oxford, US

Key dates

• Filing date: Sep 6, 2017
• Grant date: Nov 27, 2018
• Expiry date: Sep 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R1—, R2—, X, Y, and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.