Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors

US10138251B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Andreas Gollner · Wien, AT
• Christiane Kofink · Perchtoldsdorf, AT
• Juergen Ramharter · Wien, AT
• Harald WEINSTABL · Wien, AT
• Tobias Wunberg · Mödling, AT

Key dates

• Filing date: Apr 10, 2015
• Grant date: Nov 27, 2018
• Expiry date: Apr 10, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention encompasses compounds of formula (I) wherein the groups R1 to R7, V, W, X, Y, n and q are defined herein, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases and synthetic intermediates.