Antibodies that specifically bind to TL1A

US10138296B2 · kind B2 · utility

Assignee

• Cephalon LLC · US

Inventors

• Lynn Dorothy Poulton · Chatswood, AU
• Matthew Pollard · Chatswood, AU
• Anthony G. Doyle · Chatswood, AU
• Bridget A. Cooksey · Rockville, US
• Vanya Pande · Chatswood, AU
• Adam Clarke · Chatswood, AU

Key dates

• Filing date: Sep 16, 2016
• Grant date: Nov 27, 2018
• Expiry date: Sep 16, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Recombinantly expressed variant antibodies that have enhanced affinity for TL1A and enhanced potency relative to the parent antibody from which they were derived are provided. The antibodies inhibit the interaction between TL1A and the death receptor 3 (DR3). The antibodies, or a composition thereof, may be used to treat one or more of asthma, COPD, pulmonary fibrosis, cystic fibrosis, inflammatory bowel disease, a gastrointestinal disease associated with cystic fibrosis, Crohn's disease, colitis, ulcerative colitis, irritable bowel syndrome, eosinophilic esophagitis, atopic dermatitis, eczema, scleroderma, arthritis, or rheumatoid arthritis.