Anti-IL-2 antibodies and compositions and uses thereof

US10138298B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• The Board of Trustees of the Leland Stanford Junior University · US
• PFIZER INC. · US

Inventors

• Isaac J. Rondon · San Francisco, US
• Natasha Crellin · San Carlos, US
• Paul H. Bessette · Camarillo, US
• Eleonora Trotta · San Francisco, US
• Jeffrey A. Bluestone · San Francisco, US
• Lauren K. Ely · New York, US
• Kenan Christopher Garcia · Menlo Park, US

Key dates

• Filing date: Oct 21, 2016
• Grant date: Nov 27, 2018
• Expiry date: Oct 21, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2Rα and IL-2Rβ. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.