Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators
US10138465B2 · kind B2 · utility
19Cited by
78References
53Claims
0Family size
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Key dates
| Filing date | Dec 18, 2013 |
| Grant date | Nov 27, 2018 |
| Priority date | — |
| Expiry date | Aug 22, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/90
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods to promote differentiation of pluripotent stem cells to pancreatic endoderm cells expressing PDX1, NKX6.1, and HB9. In particular, the methods encompass culturing Stage 4 to Stage 6 cells with a thyroid hormone (e.g. T3), an ALK5 inhibitor, or both.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.