Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins
US10138493B2 · kind B2 · utility
2Cited by
2References
18Claims
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Key dates
| Filing date | Aug 25, 2017 |
| Grant date | Nov 27, 2018 |
| Priority date | — |
| Expiry date | Aug 25, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/002
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Embodiments disclosed herein provide artificial expression systems comprising the zinc-finger containing transcription factors and engineered promoters to modulate expression of genes of interest. Engineered zinc-finger transcription factors that interact with engineered promoters constitute synthetic and regulatable expression systems which facilitate the modulation of gene expression as desired.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.