Method for gestational age estimation and embryonic mutant detection
US10140708B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 2017 |
| Grant date | Nov 27, 2018 |
| Priority date | — |
| Expiry date | Mar 13, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30044
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
A method to characterize shape variations in brain ventricles during embryonic growth in mammals, the method including extracting a brain ventricle skeleton from one or more images, calculating a volume profile for the skeleton using the extracted images, partitioning the brain ventricle based on the volume profile along the skeleton, the brain ventricle being partitioned into two lateral ventricles and a main ventricle, the main ventricle being further partitioned into three sub regions, determining volume vectors of the two lateral ventricles and the three sub regions, computing a means square error between the determined computed volume vectors and a pretrained mean volume vector of embryos during different gestational stages, and classifying the embryo to the gestational stage having the lowest mean square error. A method to characterize mutant detection in mammals, the method including acquiring one or more images, computing a volume profile directly along a path of the detected skeleton from the one or more images, aligning the volume profile against a standard profile, and evaluating the volume profile against the standard profile to detect a mutation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.