Malic acid stabilized nanoceria particles
US10143661B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Oct 17, 2014 |
| Grant date | Dec 4, 2018 |
| Priority date | — |
| Expiry date | Oct 17, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K33/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, malic acid, an oxidant, and water, is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of nanoceria particles. Biocompatible nanoparticles comprised of ceria and malic acid are described. A reduction in cell death in a murine model of ischemic stroke utilizing intact brain slices is demonstrated by a prophylactic treatment of ceria nanoparticles prepared with malic acid.
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