Taxane analogs for the treatment of brain cancer
US10143677B2 · kind B2 · utility
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32Claims
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Key dates
| Filing date | Apr 10, 2017 |
| Grant date | Dec 4, 2018 |
| Priority date | — |
| Expiry date | Jun 27, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.