Pyrrolobenzodiazepines and conjugates thereof

US10143695B2 · kind B2 · utility

Assignee

• Mersana Therapeutics, Inc. · US

Inventors

• Mao Yin · Needham, US
• Joshua D. Thomas · Natick, US
• Aleksandr V. Yurkovetskiy · Littleton, US
• Patrick R. Conlon · Wakefield, US
• Bingfan Du · Cambridge, US
• Eugene Kelleher · Somerville, US
• Timothy B. Lowinger · Carlisle, US
• Shuyi Tang · Shanghai, CN

Key dates

• Filing date: May 17, 2017
• Grant date: Dec 4, 2018
• Expiry date: May 17, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates generally to derivatives of pyrrolobenzodiazepines and antibody-drug conjugates thereof and to methods of using these conjugates as therapeutics and/or diagnostics.