Mutant organophosphorus acid anhydrolase enzymes with stereospecificity on Sarin enantiomers and uses thereof
US10143874B1 · kind B1 · utility
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Key dates
| Filing date | Sep 21, 2017 |
| Grant date | Dec 4, 2018 |
| Priority date | — |
| Expiry date | Sep 21, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA62D2101/26
- WIPO fieldMachine tools
- WIPO sectorMechanical engineering
Abstract
Disclosed herein are non-wild-type organophosphorus acid anhydrolases having three site mutations, methods of production, and methods of use to effectively degrade toxic chemicals such as((RS)-Propan-2-yl methylphosphonofluoridate)(Sarin) and other organophosphorus compounds. Also provided are organophosphorus acid anhydrolase mutants capable of degrading Sarin with distinct selective stereospecificity preferences differing from the wild-type organophosphorus acid anhydrolase
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.