Pyrazolo[1,5-A]PYRAZIN-4-YL derivatives

US10144738B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Matthew Frank Brown · Stonington, US
• Alpay Dermenci · East Lyme, US
• Andrew Fensome · Wayne, US
• Brian Stephen Gerstenberger · Brookline, US
• Matthew Merrill Hayward · Old Lyme, US
• Dafydd Rhys Owen · Concord, US
• Stephen Wayne Wright · Old Lyme, US
• Li Xing · Lexington, US
• Xiaojing Yang · Waterford, US

Key dates

• Filing date: Feb 21, 2017
• Grant date: Dec 4, 2018
• Expiry date: Feb 21, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound having the structure: or a pharmaceutically acceptable salt thereof, wherein A, A′ and A″ are independently O, C═O, etc.; R0 and R are independently H, Br, Cl, F, or C1-C6 alkyl; R1 is H, C1-C6 alkyl, or hydroxy(C1-C6 alkyl); R2 is selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, etc.; R6, R7 and R8 are each independently H, C1-C6 alkyl, C1-C4 alkoxy(C1-C6 alkyl), etc.; and, n is 0, 1, 2 or 3. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations thereof with other therapeutic agents.