Methods and compositions for the treatment and/or prophylaxis of Clostridium difficile associated disease

US10144775B2 · kind B2 · utility

Assignee

• IMMURON LIMITED · AU

Inventors

• Dena Lyras · Melbourne, AU
• Melanie Hutton · Melbourne, AU
• Bliss Cunningham · Cockatoo, AU
• Lucy Li · San Francisco, US
• Glen Carter · Melbourne, AU
• Julian Ian Rood · Melbourne, AU

Key dates

• Filing date: Apr 17, 2014
• Grant date: Dec 4, 2018
• Expiry date: Apr 17, 2034

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methods and compositions for the treatment and/or prophylaxis of Clostridium difficile associated disease (CD AD). In particular, the invention relates to antibodies that bind to C. difficile antigens and are capable of inhibiting C. difficile infection, at least one symptom of C. difficile associated disease, shedding of C. difficile, and C. difficile associated mortality. The compositions of the present application comprise: mammalian or avian antibodies which bind to a C. difficile Toxin B; and mammalian or avian antibodies that bind to a C. difficile vegetative cell antigen and/or a C. difficile endospore antigen.