Synthesis of cleavable fluorescent nucleotides as reversible terminators for DNA sequencing by synthesis

US10144961B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Jingyue Ju · Englewood Cliffs, US
• Huanyan Cao · Jiangyin, CN
• Zengmin Li · Great Neck, US
• Qinglin Meng · Sunnyvale, US
• Jia Guo · Chandler, US
• Shenglong Zhang · Lo Wu, CN
• Lin Yu · San Diego, US

Key dates

• Filing date: May 16, 2017
• Grant date: Dec 4, 2018
• Expiry date: May 16, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2537/157
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides novel azido linkers for deoxynucleotide analogs having a detectable marker attached thereto.