Integrated method for three-dimensional visualization reconstruction of the fascicular structure inside human peripheral nerves

US10147228B2 · kind B2 · utility

Assignees

• THE FIRST AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY · CN
• SCHOOL OF DATA AND COMPUTER SCIENCE OF SUN YAT-SEN UNIVERSITY · CN
• NATIONAL SUPERCOMPUTER CENTRE IN GUANGZHOU OF SUN YAT-SEN UNIVERSITY · CN

Inventors

• Liwei Yan · Tangxia, CN
• Shuang-Kun Zhu · Shanghai, CN
• Xiaolin Liu · 流花街道, CN
• Jian Qi · Tangxia, CN
• Qingtang Zhu · Tangxia, CN
• Yao Lu · Beijing, CN
• Yongze Guo · Tangxia, CN
• Sha Yu · Tangxia, CN
• Yutong Lu · Longbeilingcun, CN
• Xi Zhang · Longbeilingcun, CN
• Yunfei Du · Tangxia, CN
• Tao Lin · Tangxia, CN

Key dates

• Filing date: Jun 14, 2017
• Grant date: Dec 4, 2018
• Expiry date: Aug 9, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2215/16
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to fields of clinical application of nerve defect repair and the medical three-dimensional (3D) printing technology, and provides an integrated visualization method for three-dimensional (3D) reconstruction of internal structure of human peripheral nerves. The method comprises the following steps: obtaining human peripheral nerves, preparing nerve specimens ex vivo by staining with an iodine preparation in combination with a freeze-drying method; scanning the pretreated peripheral nerves using Micro CT to acquire lossless two-dimensional images, and performing binarization processing to the two-dimensional images, then conducting image segmentation based on textural features to acquire images of nerve fascicles; finally, reconstructing the segmented images into a visualization model by using a supercomputer.