Magnetic resonance imaging (MRI) based quantitative kidney perfusion analysis
US10147314B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 20, 2013 |
| Grant date | Dec 4, 2018 |
| Priority date | — |
| Expiry date | Apr 16, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/58
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Example apparatus and methods provide improved spatial and temporal resolution over conventional magnetic resonance renography (MRR). Example apparatus and methods reconstruct under-sampled three-dimensional (3D) data associated with nuclear magnetic resonance (NMR) signals acquired from a kidney. The data is reconstructed using a 3D through-time non-Cartesian generalized auto-calibrating partially parallel acquisitions (GRAPPA) approach. Example apparatus and methods produce a quantized value for a contrast agent concentration in the kidney from a signal intensity in the data based, at least in part, on a two compartment model of the kidney. The two compartment model includes a plasma compartment and a tubular compartment. The quantized value describes a perfusion parameter for the kidney or a filtration parameter for the kidney. Greater precision is achieved for estimates of the perfusion parameter or filtration parameter as a result of the quantization performed on data acquired with greater spatial resolution and temporal resolution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.