Methods and compositions for vein harvest and autografting

US10149470B2 · kind B2 · utility

Assignees

• VANDERBILT UNIVERSITY · US
• THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERNS AFFAIRS · US

Inventors

• Colleen Brophy · Nashville, US
• Padmini Komalavilas · Tempe, US
• Joyce Cheung-Flynn · Nashville, US
• Kyle Hocking · Nashville, US
• Susan Eagle · Nashville, US

Key dates

• Filing date: Sep 27, 2016
• Grant date: Dec 11, 2018
• Expiry date: Sep 27, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P41/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.