Compound of 3-hydroxyl pyridine, preparation method thereof and pharmaceutical use thereof

US10149841B2 · kind B2 · utility

Assignee

• Shenyang Sunshine Pharmaceutical Co., LTD · CN

Inventors

• Yunlong Zhou · Suzhou, CN
• Suixiong Cai · 安丰镇, CN
• Guangfeng Wang · Shanghai, CN
• Lingling Jiao · Taizhou City, CN
• Ping Min · Shanghai, CN
• Yu Jing · Suzhou, CN
• Ming Guo · Suzhou, CN

Key dates

• Filing date: Dec 14, 2015
• Grant date: Dec 11, 2018
• Expiry date: Dec 14, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of the following formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently H; R3 is selected from H, a C1-C7 straight-chain, and a branched or cyclic alkyl; and R4, R5, R6, R7, and R8 are each independently selected from C1-C7 alkyl, halo C1-C7 alkyl and the like. Also provided is a method for preparing the compound, pharmaceutical compositions including the compound or pharmaceutically acceptable salts thereof, and uses of the compound or pharmaceutically acceptable salt thereof in the preparation of a medicine for inhibiting HIF prolyl hydroxylase or a medicine for promoting the generation of endogenous EPO.