Engineered collagen matrices for myocardial therapy
US10149922B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 30, 2014 |
| Grant date | Dec 11, 2018 |
| Priority date | — |
| Expiry date | May 2, 2035 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/20
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Disclosed is a patch system for use in a patient with a damaged heart. The patch comprises both a biodegradable engineered collagen scaffold to provide structural support to the injured heart and therapeutic agents, which are delivered by the patch to the heart. The scaffold consists of a dense collagen lamella produced by plastic compression with biomechanical properties that make it compatible with beating heart tissue, e.g. stiffness in a predefined range. One therapeutic agent, Fstl1, is shown to induce cardiomyocyte proliferation and enhance cardiac regeneration after injury. The patch can also be loaded with functionalized nanoparticles to yield multi-modal imaging capabilities in vivo. Also disclosed is a method for implanting the patch onto a patient's heart.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.