Compounds for use in preparing heterocyclic triazole agonists of the APJ receptor

US10150760B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Xiaoqi Chen · Palo Alto, US
• Alan C. Cheng · Cambridge, US
• Richard V. Connors · Mesa, US
• Mikkel V. Debenedetto · Shrewsbury, US
• Paul John Dransfield · Arlington, US
• Zice Fu · Foster City, US
• James S. Harvey · Arlington, US
• Julie Anne Heath · Chico, US
• Jonathan Houze · Cambridge, US
• Ted Judd · San Fernando, US
• David John Kopecky · West Hollywood, US
• Su-Jen Lai · Somerville, US
• Zhihua Ma · Lexington, US
• Nobuko Nishimura · Calabasas, US
• Steven H. Olson · Millbrae, US
• Vatee Pattaropong · Bedford, US
• Xiaodong Wang · Zhejiang, CN

Key dates

• Filing date: Apr 5, 2018
• Grant date: Dec 11, 2018
• Expiry date: Apr 5, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small molecule agonists of the APJ Receptor: where the definitions of the variables are provided herein.