Catalytic oxidation of polar modifiers in chromatographic mobile phases
US10151733B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 12, 2014 |
| Grant date | Dec 11, 2018 |
| Priority date | — |
| Expiry date | Nov 13, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/8435
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.