Methods for top-down multiplexed mass spectral analysis of mixtures of proteins or polypeptides
US10151758B2 · kind B2 · utility
2Cited by
9References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 13, 2017 |
| Grant date | Dec 11, 2018 |
| Priority date | — |
| Expiry date | Jun 3, 2037 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/0072
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Applications of ion-ion reaction chemistry are disclosed in which proton transfer reactions (PTR) and real-time data analysis methods are used to (1) simplify complex mixture analysis of samples introduced into a mass spectrometer, and (2) improve resolution and sensitivity for the analysis of large proteins in excess of 50 kDa by removing charge and reducing the collisional cross section.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.