Microneedle device having a peptide therapeutic agent and an amino acid and methods of making and using the same
US10154957B2 · kind B2 · utility
9Cited by
14References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 6, 2017 |
| Grant date | Dec 18, 2018 |
| Priority date | — |
| Expiry date | Apr 6, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2037/0053
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A medical device including an array of microneedles and a coating disposed on or within the microneedles and a method of making such a device are disclosed. The coating includes a peptide therapeutic agent and an amino acid. A method of stabilizing a peptide therapeutic agent with an amino acid on an array of microneedles is also disclosed. In some cases, the peptide therapeutic agent and the amino acid either both have a net positive charge or both have a net negative charge. In some cases, the peptide therapeutic agent is histidine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.