Selective reduction of morphinan alkaloids
US10155771B2 · kind B2 · utility
0Cited by
4References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 4, 2016 |
| Grant date | Dec 18, 2018 |
| Priority date | — |
| Expiry date | Nov 4, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure relates to selective reduction of morphinan alkaloids in a continuous flow system. In particular, the present disclosure relates to selective reduction of thebaine or oripavine using hydrazine or a hydrazine-containing compound in a continuous flow system under elevated temperature and pressure condition to form 8,14-dihydrothebaine or 8,14-dihydrooripavine, respectively.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.